Targeting OPA1-Mediated Mitochondrial Fusion Contributed to Celastrol's Anti-Tumor Angiogenesis Effect

• Main Authors: Gaofu Li (Author), Lei Zhou (Author), Huifang Deng (Author), Congshu Huang (Author), Ningning Wang (Author), Lanxin Yue (Author), Pengfei Zhang (Author), Yongqiang Zhou (Author), Wei Zhou (Author), Yue Gao (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Celastrol, an active triterpenoid extracted from one of the most famous traditional Chinese medicines (TCMs), <i>Tripterygium wilfordii</i> Hook.f., is a novel anti-cancer drug with significant anti-angiogenesis activity. However, the exact molecular mechanisms underlying its anti-tumor...