SDF-1/CXCL12 and CXCR4 gene variants, and elevated serum SDF-1 levels are associated with preeclampsia

Objective: We aimed to compare the frequencies of stromal cell-derived factor-1 (SDF-1) 3'A and CXCR4 single-nucleotide polymorphisms (SNPs) and serum SDF-1 levels in patients with preeclampsia (PE). Methods: In total, 89 women with PE and 89 control women were included in the study. Genotyping...

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Main Authors: Savas Karakus (Author), Binnur Bagci (Author), Gokhan Bagci (Author), Enver Sancakdar (Author), Caglar Yildiz (Author), Ozlem Akkar (Author), Ali Cetin (Author)
Format: Book
Published: Taylor & Francis Group, 2017-04-01T00:00:00Z.
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001 doaj_01c7dda3d2014ddb9e60c08bfc930d9d
042 |a dc 
100 1 0 |a Savas Karakus  |e author 
700 1 0 |a Binnur Bagci  |e author 
700 1 0 |a Gokhan Bagci  |e author 
700 1 0 |a Enver Sancakdar  |e author 
700 1 0 |a Caglar Yildiz  |e author 
700 1 0 |a Ozlem Akkar  |e author 
700 1 0 |a Ali Cetin  |e author 
245 0 0 |a SDF-1/CXCL12 and CXCR4 gene variants, and elevated serum SDF-1 levels are associated with preeclampsia 
260 |b Taylor & Francis Group,   |c 2017-04-01T00:00:00Z. 
500 |a 1064-1955 
500 |a 1525-6065 
500 |a 10.1080/10641955.2016.1250904 
520 |a Objective: We aimed to compare the frequencies of stromal cell-derived factor-1 (SDF-1) 3'A and CXCR4 single-nucleotide polymorphisms (SNPs) and serum SDF-1 levels in patients with preeclampsia (PE). Methods: In total, 89 women with PE and 89 control women were included in the study. Genotyping was done by polymerase chain reaction-restriction fragment length polymorphism method. Enzyme-linked immunosorbent assay method was used to measure serum SDF-1 level. Results: For SDF-1 3'A SNP, the frequency of GA genotype, total number of GA and AA genotypes, and the A allele frequency was higher in PE patients than controls (p = 0.04, 0.023, and 0.029, respectively). For CXCR4 SNP, the frequency of CT genotype, total number of CT and TT genotypes, and the T allele frequency were higher in PE patients than controls (p = 0.04, 0.006, and 0.005, respectively). SDF-1 serum level was detected higher in preeclamptic women compared with controls (p = 0.001). In PE patients, there was no significant association between serum SDF-1 levels and genotypes of SDF-1 3'A SNP. SDF-1 level was significantly higher in patients bearing CXCR4 CT genotype than CC genotype (p = 0.001). Furthermore, SDF-1 levels in patients bearing CT+TT genotype were found higher than that of patients with CC genotypes (p = 0.001). Conclusion: Results of our study suggest that SDF-1 3'A and CXCR4 polymorphisms and elevated serum SDF-1 levels may have a role in the development of PE. 
546 |a EN 
690 |a cxcl12 gene 
690 |a cxcr4 gene 
690 |a sdf-1 
690 |a polymorphism 
690 |a preeclampsia 
690 |a Gynecology and obstetrics 
690 |a RG1-991 
655 7 |a article  |2 local 
786 0 |n Hypertension in Pregnancy, Vol 36, Iss 2, Pp 124-130 (2017) 
787 0 |n http://dx.doi.org/10.1080/10641955.2016.1250904 
787 0 |n https://doaj.org/toc/1064-1955 
787 0 |n https://doaj.org/toc/1525-6065 
856 4 1 |u https://doaj.org/article/01c7dda3d2014ddb9e60c08bfc930d9d  |z Connect to this object online.