SDF-1/CXCL12 and CXCR4 gene variants, and elevated serum SDF-1 levels are associated with preeclampsia
Objective: We aimed to compare the frequencies of stromal cell-derived factor-1 (SDF-1) 3'A and CXCR4 single-nucleotide polymorphisms (SNPs) and serum SDF-1 levels in patients with preeclampsia (PE). Methods: In total, 89 women with PE and 89 control women were included in the study. Genotyping...
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Taylor & Francis Group,
2017-04-01T00:00:00Z.
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LEADER | 00000 am a22000003u 4500 | ||
---|---|---|---|
001 | doaj_01c7dda3d2014ddb9e60c08bfc930d9d | ||
042 | |a dc | ||
100 | 1 | 0 | |a Savas Karakus |e author |
700 | 1 | 0 | |a Binnur Bagci |e author |
700 | 1 | 0 | |a Gokhan Bagci |e author |
700 | 1 | 0 | |a Enver Sancakdar |e author |
700 | 1 | 0 | |a Caglar Yildiz |e author |
700 | 1 | 0 | |a Ozlem Akkar |e author |
700 | 1 | 0 | |a Ali Cetin |e author |
245 | 0 | 0 | |a SDF-1/CXCL12 and CXCR4 gene variants, and elevated serum SDF-1 levels are associated with preeclampsia |
260 | |b Taylor & Francis Group, |c 2017-04-01T00:00:00Z. | ||
500 | |a 1064-1955 | ||
500 | |a 1525-6065 | ||
500 | |a 10.1080/10641955.2016.1250904 | ||
520 | |a Objective: We aimed to compare the frequencies of stromal cell-derived factor-1 (SDF-1) 3'A and CXCR4 single-nucleotide polymorphisms (SNPs) and serum SDF-1 levels in patients with preeclampsia (PE). Methods: In total, 89 women with PE and 89 control women were included in the study. Genotyping was done by polymerase chain reaction-restriction fragment length polymorphism method. Enzyme-linked immunosorbent assay method was used to measure serum SDF-1 level. Results: For SDF-1 3'A SNP, the frequency of GA genotype, total number of GA and AA genotypes, and the A allele frequency was higher in PE patients than controls (p = 0.04, 0.023, and 0.029, respectively). For CXCR4 SNP, the frequency of CT genotype, total number of CT and TT genotypes, and the T allele frequency were higher in PE patients than controls (p = 0.04, 0.006, and 0.005, respectively). SDF-1 serum level was detected higher in preeclamptic women compared with controls (p = 0.001). In PE patients, there was no significant association between serum SDF-1 levels and genotypes of SDF-1 3'A SNP. SDF-1 level was significantly higher in patients bearing CXCR4 CT genotype than CC genotype (p = 0.001). Furthermore, SDF-1 levels in patients bearing CT+TT genotype were found higher than that of patients with CC genotypes (p = 0.001). Conclusion: Results of our study suggest that SDF-1 3'A and CXCR4 polymorphisms and elevated serum SDF-1 levels may have a role in the development of PE. | ||
546 | |a EN | ||
690 | |a cxcl12 gene | ||
690 | |a cxcr4 gene | ||
690 | |a sdf-1 | ||
690 | |a polymorphism | ||
690 | |a preeclampsia | ||
690 | |a Gynecology and obstetrics | ||
690 | |a RG1-991 | ||
655 | 7 | |a article |2 local | |
786 | 0 | |n Hypertension in Pregnancy, Vol 36, Iss 2, Pp 124-130 (2017) | |
787 | 0 | |n http://dx.doi.org/10.1080/10641955.2016.1250904 | |
787 | 0 | |n https://doaj.org/toc/1064-1955 | |
787 | 0 | |n https://doaj.org/toc/1525-6065 | |
856 | 4 | 1 | |u https://doaj.org/article/01c7dda3d2014ddb9e60c08bfc930d9d |z Connect to this object online. |