Delivery of pDNA to the Lung by Lipopolyplexes Using <i>N</i>-Lauroylsarcosine and Effect on the Pulmonary Fibrosis

• Main Authors: Tomoaki Kurosaki (Author), Hiroki Kanda (Author), Junya Hashizume (Author), Kayoko Sato (Author), Hitomi Harasawa (Author), Tadahiro Nakamura (Author), Hitoshi Sasaki (Author), Yukinobu Kodama (Author)
• Format: Book
• Published: MDPI AG, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In a previous study, we constructed a lung-targeting lipopolyplex containing polyethyleneimine (PEI), 1,2-di-<i>O</i>-octadecenyl-3-trimethylammonium propane (DOTMA), and <i>N</i>-lauroylsarcosine (LS). The lipopolyplex exhibited an extremely high gene expression in the lung...