Dose-Finding Study and Pharmacokinetics Profile of the Novel 13-Mer Antisense miR-221 Inhibitor in Sprague-Dawley Rats

• Autori principali: Maria Teresa Di Martino (Autore), Mariamena Arbitrio (Autore), Daniele Caracciolo (Autore), Francesca Scionti (Autore), Pierosandro Tagliaferri (Autore), Pierfrancesco Tassone (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2020-06-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

miR-221 is overexpressed in several malignancies where it promotes tumor growth and survival by interfering with gene transcripts, including p27Kip1, PUMA, PTEN, and p57Kip2. We previously demonstrated that a novel 13-mer miR-221 inhibitor (locked nucleic acid [LNA]-i-miR-221) exerts antitumor activ...