Does diabetes mellitus affect guided bone regeneration outcomes in individuals undergoing dental implants? A systematic review and meta-analysis

ObjectivesThis systematic review aimed to verify if diabetes affects vertical and horizontal ridge augmentation in individuals undergoing dental implant treatment with guided bone regeneration (GBR).MethodsFive databases were systematically screened up to September 2023, according to predefined elig...

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Main Authors: Leandro Machado Oliveira (Author), Fabricio Batistin Zanatta (Author), Raquel Pippi Antoniazzi (Author), Patrícia Almeida Miguez (Author)
Format: Book
Published: Frontiers Media S.A., 2024-01-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Leandro Machado Oliveira  |e author 
700 1 0 |a Fabricio Batistin Zanatta  |e author 
700 1 0 |a Raquel Pippi Antoniazzi  |e author 
700 1 0 |a Patrícia Almeida Miguez  |e author 
245 0 0 |a Does diabetes mellitus affect guided bone regeneration outcomes in individuals undergoing dental implants? A systematic review and meta-analysis 
260 |b Frontiers Media S.A.,   |c 2024-01-01T00:00:00Z. 
500 |a 2673-4915 
500 |a 10.3389/fdmed.2024.1352763 
520 |a ObjectivesThis systematic review aimed to verify if diabetes affects vertical and horizontal ridge augmentation in individuals undergoing dental implant treatment with guided bone regeneration (GBR).MethodsFive databases were systematically screened up to September 2023, according to predefined eligibility criteria. The methodological risk of bias of the included studies was assessed using the ROBINS-I tool, and GRADE was used to evaluate the certainty of evidence. Random-effects pairwise meta-analyses were used to compare changes in vertical (height) and horizontal (width) alveolar bone dimensions between individuals exposed and unexposed to diabetes, through standardized mean differences (SMDs).ResultsThree non-randomized controlled trials met the inclusion criteria, all of which showed a serious risk of bias. The results showed, with overall very low certainty on evidence, that individuals with diabetes did not exhibit a significant difference in horizontal (SMD = −0.41, 95% CI: −0.92-0.10) and vertical (SMD = 0.06, 95% CI: −0.43-0.56) ridge augmentation compared to the those without diabetes.ConclusionsThe available evidence, albeit of very low certainty, suggests that diabetic individuals with moderate or good glycemic control undergoing dental implants and GBR show comparable horizontal and vertical bone gains to their unexposed counterparts. Systematic Review Registrationhttps://osf.io/bpx3t. 
546 |a EN 
690 |a alveolar ridge augmentation 
690 |a dental implants 
690 |a diabetes mellitus 
690 |a systematic review 
690 |a meta-analysis 
690 |a Dentistry 
690 |a RK1-715 
655 7 |a article  |2 local 
786 0 |n Frontiers in Dental Medicine, Vol 5 (2024) 
787 0 |n https://www.frontiersin.org/articles/10.3389/fdmed.2024.1352763/full 
787 0 |n https://doaj.org/toc/2673-4915 
856 4 1 |u https://doaj.org/article/02ebd273e84f42b0a2d1f635b2c20fcf  |z Connect to this object online.