Exploration of Novel Urolithin C Derivatives as Non-Competitive Inhibitors of Liver Pyruvate Kinase

• Main Authors: Umberto Maria Battisti (Author), Leticia Monjas (Author), Fady Akladios (Author), Josipa Matic (Author), Eric Andresen (Author), Carolin H. Nagel (Author), Malin Hagkvist (Author), Liliana Håversen (Author), Woonghee Kim (Author), Mathias Uhlen (Author), Jan Borén (Author), Adil Mardinoğlu (Author), Morten Grøtli (Author)
• Format: Bog
• Udgivet: MDPI AG, 2023-04-01T00:00:00Z.
• Fag: article
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The inhibition of liver pyruvate kinase could be beneficial to halt or reverse non-alcoholic fatty liver disease (NAFLD), a progressive accumulation of fat in the liver that can lead eventually to cirrhosis. Recently, urolithin C has been reported as a new scaffold for the development of allosteric...