Hypoglycemic, hepatoprotective and molecular docking studies of 5-[(4-chlorophenoxy) methyl]-1, 3, 4-oxadiazole-2-thiol

• Main Authors: Naureen Shehzadi (Author), Khalid Hussain (Author), Nadeem Irfan Bukhari (Author), Muhammad Islam (Author), Muhammad Tanveer Khan (Author), Muhammad Salman (Author), Sabahat Zahra Siddiqui (Author), Aziz Ur Rehman (Author), Muhammad Athar Abbasi (Author)
• Format: Book
• Published: Bangladesh Pharmacological Society, 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The present study aimed at the evaluation of anti-hyperglycemic and hepatoprotective potential of a new drug candidate, 5-[(4-chlorophenoxy) methyl]-1,3,4-oxadiazole-2-thiol (OXCPM) through in vitro and in vivo assays, respectively. The compound displayed excellent dose-dependent ɑ-amylase (28.0-92....