Gene polymorphisms of uric acid are associated with pre-eclampsia in South Africans of African ancestry
Objectives To investigate the association of uric acid gene polymorphisms and Pre-eclampsia. Methods 637 women of African ancestry [280 controls, 357 pre-eclampsia (early-onset = 187, late-onset = 170]) retrospectively. The rs505802, rs1212986, and rs1014290 SNPs were genotyped from purified DNA usi...
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| Main Authors: | , , , , |
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| Format: | Book |
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Taylor & Francis Group,
2020-04-01T00:00:00Z.
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| Summary: | Objectives To investigate the association of uric acid gene polymorphisms and Pre-eclampsia. Methods 637 women of African ancestry [280 controls, 357 pre-eclampsia (early-onset = 187, late-onset = 170]) retrospectively. The rs505802, rs1212986, and rs1014290 SNPs were genotyped from purified DNA using real-time PCR. Results CT genotype (rs505802) was higher in pre-eclampsia [Adjusted p = 0.028*: OR (95% CI) = 1.73 (1.258-2.442)] and late-onset pre-eclampsia [Adjusted p = 0.027*: OR (95% CI) = 1.75 (1.165-2.2628)] than controls. CT genotype (rs1014290) was higher in early-onset pre-eclampsia [Adjusted p-value = 0.040*: OR (95% CI) = 1.60 (1.102-2.325)] than controls. Conclusion The genotyped rs505802 and rs1014290 are significantly associated with pre-eclampsia |
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| Item Description: | 1064-1955 1525-6065 10.1080/10641955.2020.1741608 |