Dasiglucagon Effects on QTc in Healthy Volunteers: A Randomized, Placebo-Controlled, Dose-Escalation, Double-Blind Study

• Main Authors: Ramin Tehranchi, MD, PhD, MBA (Author), Jonas Pettersson, MD, PhD (Author), Anita E. Melgaard, MSc (Author), Friedeborg Seitz, MD (Author), Anders Valeur, PhD (Author), Stine Just Maarbjerg, PhD (Author)
• Format: Book
• Published: Elsevier, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACT: Background: Dasiglucagon is a novel glucagon analog that is stable in aqueous formulation and approved for use in severe hypoglycemia. Concentration-QTc analyses are critical for assessing risk of drug-induced QTc prolongation and potential for fatal cardiac arrhythmias such as torsades de...