Immunological profile of HTLV-1-infected patients associated with infectious or autoimmune dermatological disorders.

• Main Authors: Jordana Grazziela Alves Coelho- (Author), Livia Passos (Author), Mariana Costa Duarte (Author), Marcelo Grossi Araújo (Author), Ana Carolina Campi-Azevedo (Author), Andréa Teixeira-Carvalho (Author), Vanessa Peruhype-Magalhães (Author), Bruno Caetano Trindade (Author), Raquel Dos Santos Dias (Author), Marina Lobato Martins (Author), Anna Barbara de Freitas Carneiro-Proietti (Author), Antônio Carlos Guedes (Author), Denise Utsch Gonçalves (Author), Olindo Assis Martins-Filho (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

In the present study, the frequency, the activation and the cytokine and chemokine profile of HTLV-1 carriers with or without dermatological lesions were thoroughly described and compared. The results indicated that HTLV-1-infected patients with dermatological lesions have distinct frequency and activation status when compared to asymptomatic carriers. Alterations in the CD4(+)HLA-DR(+), CD8(+) T cell, macrophage-like and NKT subsets as well as in the serum chemokines CCL5, CXCL8, CXCL9 and CXCL10 were observed in the HTLV-1-infected group with skin lesions. Additionally, HTLV-1 carriers with dermatological skin lesions showed more frequently high proviral load as compared to asymptomatic carriers. The elevated proviral load in HTLV-1 patients with infectious skin lesions correlated significantly with TNF-α/IL-10 ratio, while the same significant correlation was found for the IL-12/IL-10 ratio and the high proviral load in HTLV-1-infected patients with autoimmune skin lesions. All in all, these results suggest a distinct and unique immunological profile in the peripheral blood of HTLV-1-infected patients with skin disorders, and the different nature of skin lesion observed in these patients may be an outcome of a distinct unbalance of the systemic inflammatory response upon HTLV-1 infection.

Item Description

1935-2727
1935-2735
10.1371/journal.pntd.0002328