Efficacy of vitamin C and ethanolic extract of Sesamum indicum in promoting fertility in male Wistar rats

Aims: This study investigates the efficacy of ethanolic extract of Sesamum indicum (EES), vitamin C (VC), and EES + VC in promoting fertility and finding a possible link between their profertility effects and their antioxidant activities. Materials and Methods: Forty adult male Wistar rats [Body wei...

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Main Authors: E A Ashamu (Author), E O Salawu (Author), O O Oyewo (Author), A W Alhassan (Author), O A Alamu (Author), A A Adegoke (Author)
Format: Book
Published: Wolters Kluwer Medknow Publications, 2010-01-01T00:00:00Z.
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042 |a dc 
100 1 0 |a E A Ashamu  |e author 
700 1 0 |a E O Salawu  |e author 
700 1 0 |a O O Oyewo  |e author 
700 1 0 |a A W Alhassan  |e author 
700 1 0 |a O A Alamu  |e author 
700 1 0 |a A A Adegoke  |e author 
245 0 0 |a Efficacy of vitamin C and ethanolic extract of Sesamum indicum in promoting fertility in male Wistar rats 
260 |b Wolters Kluwer Medknow Publications,   |c 2010-01-01T00:00:00Z. 
500 |a 0974-1208 
500 |a 1998-4766 
500 |a 10.4103/0974-1208.63115 
520 |a Aims: This study investigates the efficacy of ethanolic extract of Sesamum indicum (EES), vitamin C (VC), and EES + VC in promoting fertility and finding a possible link between their profertility effects and their antioxidant activities. Materials and Methods: Forty adult male Wistar rats [Body weight (BW) 186.56 ± 0.465 g] were randomly analyzed into four groups of ten rats each: Control, EES G (EES only), VC G (vitamin C only), and EES + VC G (EES in conjunction with vitamin C). Control was given 5 ml/kg BW/day of normal saline orally; EES G was administered 0.3 g/kg BW/day of EES; VC G was administered 15 mg/kg BW/ day of VC; while EES + VC G was administered both 0.3 g/kg BW/day of EES and 15 mg/kg BW/day of VC. All treatments were for 10 weeks. Statistical Analysis Used: Independent-sample T test was used to analyze the obtained results. Results: The results obtained showed that EES, VC, and more importantly EES + VC are capable of significantly increasing BW gain, seminal parameters, testosterone level, and body antioxidant activities. Conclusions: These findings lead to the conclusion that EES + VC as well as ESS and VC promote fertility due to both their testosterone-increasing effects and their antioxidant effects. 
546 |a EN 
690 |a Antioxidant 
690 |a fertility 
690 |a Sesamum indicum 
690 |a sperm count 
690 |a vitamin C 
690 |a Gynecology and obstetrics 
690 |a RG1-991 
655 7 |a article  |2 local 
786 0 |n Journal of Human Reproductive Sciences, Vol 3, Iss 1, Pp 11-14 (2010) 
787 0 |n http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2010;volume=3;issue=1;spage=11;epage=14;aulast=Ashamu 
787 0 |n https://doaj.org/toc/0974-1208 
787 0 |n https://doaj.org/toc/1998-4766 
856 4 1 |u https://doaj.org/article/03b13e2e6bc047c8a76b95e836c184e6  |z Connect to this object online.