IL-34 Downregulation‒Associated M1/M2 Macrophage Imbalance Is Related to Inflammaging in Sun-Exposed Human Skin

Macrophages can be polarized into two subsets: a proinflammatory (M1) or an anti-inflammatory (M2) phenotype. In this study, we show that an increased M1-to-M2 ratio associated with a decrease in IL-34 induces skin inflammaging. The total number of macrophages in the dermis did not change, but the n...

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Main Authors: Satoshi Horiba (Author), Ryota Kami (Author), Taiki Tsutsui (Author), Junichi Hosoi (Author)
Format: Book
Published: Elsevier, 2022-05-01T00:00:00Z.
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