Advanced Resistance Studies Identify Two Discrete Mechanisms in <i>Staphylococcus aureus</i> to Overcome Antibacterial Compounds that Target Biotin Protein Ligase

• Glavni autori: Andrew J. Hayes (Autor), Jiulia Satiaputra (Autor), Louise M. Sternicki (Autor), Ashleigh S. Paparella (Autor), Zikai Feng (Autor), Kwang J. Lee (Autor), Beatriz Blanco-Rodriguez (Autor), William Tieu (Autor), Bart A. Eijkelkamp (Autor), Keith E. Shearwin (Autor), Tara L. Pukala (Autor), Andrew D. Abell (Autor), Grant W. Booker (Autor), Steven W. Polyak (Autor)
• Format: Knjiga
• Izdano: MDPI AG, 2020-04-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Biotin protein ligase (BPL) inhibitors are a novel class of antibacterial that target clinically important methicillin-resistant <i>Staphylococcus aureus</i> (<i>S. aureus</i>). In <i>S. aureus,</i> BPL is a bifunctional protein responsible for enzymatic biotinyla...