Cover Image

Reverse of Acute and Chronic Morphine Tolerance by Lithocholic Acid via Down-regulating UGT2B7

Lithocholic acid (LCA) deposited in human livers always induces drastic pains which need analgesic drug, like morphine to release. Our research showed that LCA can effectively inhibit uridine 5'-diphospho-glucuronosyltransferase 2B7 (UGT2B7) in morphine tolerance-like human normal liver cells,...

Full description

Saved in:

Bibliographic Details
Main Authors:	Zizhao Yang (Author), Li Li (Author), Haihong Hu (Author), Mingcheng Xu (Author), Jingkai Gu (Author), Zaijie Jim Wang (Author), Lushan Yu (Author), Su Zeng (Author)
Format:	Book
Published:	Frontiers Media S.A., 2016-11-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

The Effect of Lithocholic Acid on the Gut-Liver Axis
by: Wei Sheng, et al.
Published: (2022)

PBPK Model of Morphine Incorporating Developmental Changes in Hepatic OCT1 and UGT2B7 Proteins to Explain the Variability in Clearances in Neonates and Small Infants
by: Chie Emoto, et al.
Published: (2018)

Attenuation of morphine tolerance and dependence by thymoquinone in mice
by: Hossein Hosseinzadeh, et al.
Published: (2016)

Effects of valsartan on morphine tolerance and dependence in rats
by: Ayat Kaeidi, et al.
Published: (2021)

Monoclonal antibody targeting mu-opioid receptor attenuates morphine tolerance via enhancing morphine-induced receptor endocytosis
by: Jia-Jia Zhang, et al.
Published: (2023)

The effect of metformin on morphine analgesic tolerance and dependence in rats
by: Iman Fatemi, et al.
Published: (2018)

The Influence of Contextual Cue on Antinociceptive Tolerance and Facilitation of Memory With Morphine
by: Mototaka Nakama-Kitamura, et al.
Published: (2003)

Microglia in morphine tolerance: cellular and molecular mechanisms and therapeutic potential
by: Xiangning Zhang, et al.
Published: (2024)

Inhibition of Histone Deacetylases Attenuates Morphine Tolerance and Restores MOR Expression in the DRG of BCP Rats
by: Xiao-Tao He, et al.
Published: (2018)

Studies on a novel regimen for management of orofacial pain and morphine tolerance
by: Yu-Hsien Lee, et al.
Published: (2018)

Experimental assessment of ladasten and GB-115 effects on the antinociceptive tolerance to morphine
by: M. A. Konstantinopolsky, et al.
Published: (2016)

The Extract of <i>Corydalis yanhusuo</i> Prevents Morphine Tolerance and Dependence
by: Lamees Alhassen, et al.
Published: (2021)

Deoxycholic Acid and Lithocholic Acid Alleviate Liver Injury and Inflammation in Mice with Klebsiella pneumoniae-Induced Liver Abscess and Bacteremia
by: Zheng Y, et al.
Published: (2021)

Yokukansan Inhibits the Development of Morphine Tolerance by Regulating Presynaptic Proteins in DRG Neurons
by: Yusuke Ohashi, et al.
Published: (2022)

Effect of NLRP3 inflammasome induced astrocyte phenotype alteration in morphine tolerance
by: Zhenyu Yuan, et al.
Published: (2024)

Pivotal role reelin signaling pathway in the development of tolerance to morphine-induced antinociception
by: Bambang Subakti Zulkarnanin, et al.
Published: (2008)

Xylopic acid from Xylopia aethiopica (Annonaceae) inhibits morphine tolerance in rats
by: Priscilla Kolibea Mante, et al.
Published: (2022)

Hepatoprotective Effects of Glycyrrhetinic Acid on Lithocholic Acid-Induced Cholestatic Liver Injury Through Choleretic and Anti-Inflammatory Mechanisms
by: Qian Wang, et al.
Published: (2022)

Strength, efficacy and tolerability of morphine solution with and without added preservatives: A comparative study
by: Rawshan Ara Perveen, et al.
Published: (2015)

The effect of Ocimum basilicum total extract on the development of tolerance to morphine analgesia in male rats
Published: (2017)

Profiling of UGT1A1*6, UGT1A1*60, UGT1A1*93, and UGT1A1*28 Polymorphisms in Indonesian Neonates With Hyperbilirubinemia Using Multiplex PCR Sequencing
by: Radhian Amandito, et al.
Published: (2019)

Spinal TLR4/P2X7 Receptor-Dependent NLRP3 Inflammasome Activation Contributes to the Development of Tolerance to Morphine-Induced Antinociception
by: Wang H, et al.
Published: (2020)

Integrate thermostabilized fusion protein apocytochrome b562RIL and N-glycosylation mutations: A novel approach to heterologous expression of human UDP-glucuronosyltransferase (UGT) 2B7
by: Jia Xue, et al.
Published: (2022)

Piperine Attenuates Lithocholic Acid-Stimulated Interleukin-8 by Suppressing Src/EGFR and Reactive Oxygen Species in Human Colorectal Cancer Cells
by: Shinan Li, et al.
Published: (2022)

Commentary: Profiling of UGT1A1*6, UGT1A1*60, UGT1A1*93, and UGT1A1*28 Polymorphisms in Indonesian Neonates With Hyperbilirubinemia Using Multiplex PCR Sequencing
by: Mohammad Reza Heydari, et al.
Published: (2020)

The Circadian Hormone Melatonin Inhibits Morphine-Induced Tolerance and Inflammation via the Activation of Antioxidative Enzymes
by: Ing-Jung Chen, et al.
Published: (2020)

Evaluation of the Effects of Chronic Administration of Citrus aurantium Essential Oil on the Development of Tolerance and Dependence to Morphine
by: Alireza Parvizpur, et al.
Published: (2019)

Increased glutamate synaptic transmission in the nucleus raphe magnus neurons from morphine-tolerant rats
by: Pan Zhizhong Z, et al.
Published: (2005)

Predictive Value of Serum Cholic Acid and Lithocholic Acid for the Diagnosis in an Intrahepatic Cholestasis of Pregnancy Population with High Levels of Total Bile Acids and the Correlation with Placental Hypoxia-Inducible Factor-1α
by: Cheng CY, et al.
Published: (2022)

Predictive Value of Serum Cholic Acid and Lithocholic Acid for the Diagnosis in an Intrahepatic Cholestasis of Pregnancy Population with High Levels of Total Bile Acids and the Correlation with Placental Hypoxia-Inducible Factor-1α [Corrigendum]
by: Cheng CY, et al.
Published: (2022)

Potentiation of Morphine Analgesia by Adjuvant Activation of 5-HT7 Receptors
by: Alex Brenchat, et al.
Published: (2011)

On the possible role of ERK, p38 and CaMKII in the regulation of CGRP expression in morphine-tolerant rats
by: Quirion Remi, et al.
Published: (2011)

Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with morphine
by: Rodríguez-Muñoz María, et al.
Published: (2009)

Protective effects of pistachio hydroalcoholic extract on morphine-induced analgesic tolerance and dependence: investigating the impact of oxidative stress
by: Elham Hakimizadeh, et al.
Published: (2024)

Physiologically‐Based Pharmacokinetic Modeling of the Drug-Drug Interaction of the UGT Substrate Ertugliflozin Following Co‐Administration with the UGT Inhibitor Mefenamic Acid
by: Ernesto Callegari, et al.
Published: (2021)

Inhibitory effects of tanshinones towards the catalytic activity of UDP-glucuronosyltransferases (UGTs)
by: Xu-Xin Zhang, et al.
Published: (2017)

L-cysteine ethyl ester prevents and reverses acquired physical dependence on morphine in male Sprague Dawley rats
by: James N. Bates, et al.
Published: (2023)

Genotyping of <i>UGT1A1*</i>80 as an Alternative to <i>UGT1A1*</i>28 Genotyping in Spain
by: Adrián Bravo-Gómez, et al.
Published: (2022)

Teneligliptin Co-Infusion Alleviates Morphine Tolerance by Inhibition of Spinal Microglial Cell Activation in Streptozotocin-Induced Diabetic Rats
by: Yaswanth Kuthati, et al.
Published: (2023)

Dysregulation of Vesicular Glutamate Transporter VGluT2 via BDNF/TrkB Pathway Contributes to Morphine Tolerance in Mice
by: Liqiong He, et al.
Published: (2022)