Screening of avocado oil nanoformulations intended to skin delivery

• Main Authors: Júlia Scherer Santos (Author), Julia Cristina Koppe de Conto (Author), Chana Medeiros da Silva (Author), Rosana de Cassia de Souza Scheneider (Author), Claudia Regina Müller (Author)
• Format: Book
• Published: Facultad de Farmacia, Universidad de Granada, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2340-9894; 10.30827/ars.v62i1.15486
• Keywords: avocado oil; aqueous dispersions; nanoparticles; vegetable oil.; Therapeutics. Pharmacology; RM1-950
• Source: Ars Pharmaceutica, Vol 62, Iss 1, Pp 66-74 (2021)

Abstract Introduction: vegetable ingredients are increasingly common in skin products. Avocado oil is an ingredient of natural sources with various properties on the skin. In this work, crude avocado oil-loaded nanocapsules were evaluated regarding its physicochemical stability to obtain a formulation of skin delivery with adequate quality: suitable physicochemical stability, with low polydispersity and with a pH suitable for cutaneous application. Method: nanoparticle formulations with components variation were evaluated for 2 months. Nanoparticle formulation considered the most stable was further evaluated for 6 months. Furthermore, the oxidative stability of crude avocado oil loaded in nanocapsules and standard avocado oil was also performed to detect any sign of oil oxidation. Results: all formulations had negative zeta potential after 2 months of storage. pH values of nanoparticles remained stable throughout the test. Formulation with the lowest content of ingredients exhibited the highest stability after 2 months of storage. Nanoencapsulated avocado oil and crude avocado oil showed no evidence of oxidation. Conclusions: Aqueous dispersions with the lowest content of ingredients presented the best physicochemical stability. Therefore, we have demonstrated preliminary the feasibility of developing avocado-oil loaded nanocapsules.