Modelling and Simulation of the Drug Release from a Solid Dosage Form in the Human Ascending Colon: The Influence of Different Motility Patterns and Fluid Viscosities

• Main Authors: Michael Schütt (Author), Konstantinos Stamatopoulos (Author), Hannah K. Batchelor (Author), Mark J. H. Simmons (Author), Alessio Alexiadis (Author)
• פורמט: ספר
• יצא לאור: MDPI AG, 2021-06-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

For colonic drug delivery, the ascending part of the colon is the most favourable site as it offers the most suitable environmental conditions for drug dissolution. Commonly, the performance of a drug formulation is assessed using standardised dissolution apparatus, which does not replicate the hydr...