Completing the Enalaprilat Excretion Pathway-Renal Handling by the Proximal Tubule

• Main Authors: Nori J. L. Smeets (Author), Carlijn H. C. Litjens (Author), Jeroen J. M. W. van den Heuvel (Author), Hedwig van Hove (Author), Petra van den Broek (Author), Frans G. M. Russel (Author), Jan B. Koenderink (Author), Saskia N. de Wildt (Author)
• Format: Book
• Published: MDPI AG, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Enalapril is often used in the treatment of cardiovascular diseases. Clinical data suggest that the urinary excretion of enalaprilat, the active metabolite of enalapril, is mediated by renal transporters. We aimed to identify enalaprilat specificity for renal proximal tubular transporter...