Capparis spinosa L. aqueous extract evokes antidiabetic effect in streptozotocin-induced diabetic mice
Objective: As the aqueous extract of Capparis spinosa (CS) possess antidiabetic effect, he present study aims to reveal the possible mechanism of action of CS in diabetic mice.Materials and Methods: Both single and repeated oral administrations of aqueous extract of CS were performed in multi-low d...
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Mashhad University of Medical Sciences,
2017-02-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_04a4ac12f36e44709a9d7f91398bccb3 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Mohamed Eddouks |e author |
| 700 | 1 | 0 | |a Ahmed Lemhadri |e author |
| 700 | 1 | 0 | |a Morad Hebi |e author |
| 700 | 1 | 0 | |a Ahmed EL Hidani |e author |
| 700 | 1 | 0 | |a Naoufel Ali Zeggwagh |e author |
| 700 | 1 | 0 | |a Bachir EL Bouhali |e author |
| 700 | 1 | 0 | |a Lhoussaine Hajji |e author |
| 700 | 1 | 0 | |a Remy Burcelin |e author |
| 245 | 0 | 0 | |a Capparis spinosa L. aqueous extract evokes antidiabetic effect in streptozotocin-induced diabetic mice |
| 260 | |b Mashhad University of Medical Sciences, |c 2017-02-01T00:00:00Z. | ||
| 500 | |a 2228-7930 | ||
| 500 | |a 2228-7949 | ||
| 500 | |a 10.22038/ajp.2016.7761 | ||
| 520 | |a Objective: As the aqueous extract of Capparis spinosa (CS) possess antidiabetic effect, he present study aims to reveal the possible mechanism of action of CS in diabetic mice.Materials and Methods: Both single and repeated oral administrations of aqueous extract of CS were performed in multi-low dose streptozotocin-induced (MLDS) diabetic mice. Euglycemic hyperinsulinemic clamp was used in association with the endogenous glucose production (perfusion rate of 3-3H glucose) to evaluate the effect of CS aqueous extract on insulin sensitivity.Results: Our study showed that aqueous extract of CS possess a potent hypoglycaemic activity in MLDS diabetic mice. Furthermore, the analysis perfusion of 3-3H glucose demonstrated the parallel decrease of basal endogenous glucose production (EGP) with the hypoglycaemic activity. EGP was lower in CS-Treated group when compared to the control group (p | ||
| 546 | |a EN | ||
| 690 | |a Diabetes | ||
| 690 | |a Streptozotocin | ||
| 690 | |a Insulin sensitivity | ||
| 690 | |a Mice | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Avicenna Journal of Phytomedicine, Vol 7, Iss 2, Pp 191-198 (2017) | |
| 787 | 0 | |n http://ajp.mums.ac.ir/article_7761_b203ca4b3cb6490d2d1155e2946bd6b4.pdf | |
| 787 | 0 | |n https://doaj.org/toc/2228-7930 | |
| 787 | 0 | |n https://doaj.org/toc/2228-7949 | |
| 856 | 4 | 1 | |u https://doaj.org/article/04a4ac12f36e44709a9d7f91398bccb3 |z Connect to this object online. |