Sphingosine-1-phosphate, a novel TREM2 ligand, promotes microglial phagocytosis to protect against ischemic brain injury

• Main Authors: Tengfei Xue (Author), Juan Ji (Author), Yuqin Sun (Author), Xinxin Huang (Author), Zhenyu Cai (Author), Jin Yang (Author), Wei Guo (Author), Ruobing Guo (Author), Hong Cheng (Author), Xiulan Sun (Author)
• Format: Book
• Published: Elsevier, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The mechanism of sphingosine-1-phosphate (S1P)-mediated phagocytosis remains unknown. Here, we found that S1P or FTY720 (an analog of S1P) promoted microglial phagocytosis in stroke independent of S1PRs. First, we used computer simulation of molecular docking to predict that S1P might be a ligand fo...