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Complete Growth Inhibition of <i>Pseudomonas aeruginosa</i> by Organo-Selenium-Incorporated Urinary Catheter Material

To further investigate the inhibition of <i>Pseudomonas aeruginosa</i>'s in vitro growth and biofilm formation by an organo-selenium-incorporated polyurethane (PU) catheter material. <i>P. aeruginosa</i>, <i>Staphylococcus aureus</i>, and <i>Candida alb...

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Bibliographic Details
Main Authors:	Phat L. Tran (Author), Caroline L. Presson (Author), Md Nayeem Hasan Kashem (Author), Wei Li (Author), Ted W. Reid (Author), Werner T. W. de Riese (Author)
Format:	Book
Published:	MDPI AG, 2024-08-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
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Summary:	To further investigate the inhibition of <i>Pseudomonas aeruginosa</i>'s in vitro growth and biofilm formation by an organo-selenium-incorporated polyurethane (PU) catheter material. <i>P. aeruginosa</i>, <i>Staphylococcus aureus</i>, and <i>Candida albicans</i> were incubated in vitro with organo-selenium and control polyurethane catheter materials in the presence of glutathione. Growth was evaluated by a colony-forming-unit (CFU) count and visualized with confocal laser scanning microscopy. Two different PU catheter materials were used. Using tin-catalyzed PU catheter material, complete inhibition of <i>S. aureus</i> was seen at 1% selenium (Se), whereas no inhibition was seen for <i>P. aeruginosa</i> at up to 3.0% Se. Whereas, using a thermoplastic PU catheter material, 1.5% Se and 2% Se organo-selenium caused several logs of growth inhibition of <i>P. aeruginosa</i>, and 2.5% selenium, incorporation showed complete inhibition (8 logs). Samples with lower than 1.5% selenium did not show adequate growth inhibition for <i>P. aeruginosa</i>. Similar in vitro growth inhibition was achieved against a multidrug-resistant <i>C. albicans</i> strain. It was concluded that optimal inhibition of <i>P. aeruginosa</i> in vitro growth and biofilm formation occurs with 2.5% selenium incorporated as organo-selenium in a thermoplastic PU catheter material. These results suggest that reduced incidence of CAUTIs (catheter associated urinary tract infections) with <i>P. aeruginosa</i> and other bacteria and fungi can be achieved by using organo-selenium-incorporated catheters.
Item Description:	10.3390/antibiotics13080736 2079-6382