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Bioequivalence of bisoprolol, coated tablets 10 mg JSC «Chimpharm» Republic of Kazakhstan

Within the cross, a single, open, randomized study with 10 day washout period, the two sequences has been studied bioequivalence of tablet forms two bisoprolol 18 volunteers (10 mg dosage). Plasma samples were analyzed by a validated HPLC-MS/MS within 48 hours. For preparations analyzed following ph...

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Main Authors: Y. M. Budach (Author), O. E. Kurilo (Author), A. K. Sariev (Author), D. A. Abaimov (Author), M. V. Shiryaev (Author), E. Y. Styrova (Author), S. A. Altynbekov (Author), G. A. Dzholdygulov (Author), V. N. Seryakov (Author), K. S. Altynbekov (Author)
Format: Book
Published: LLC "Publisher OKI", 2013-04-01T00:00:00Z.
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Summary:Within the cross, a single, open, randomized study with 10 day washout period, the two sequences has been studied bioequivalence of tablet forms two bisoprolol 18 volunteers (10 mg dosage). Plasma samples were analyzed by a validated HPLC-MS/MS within 48 hours. For preparations analyzed following pharmacokinetic parameters were calculated: AUC0-t, Cmax, Tmax , Cmax /AUC. 90% confidence interval for log-transformed values for AUC0-t was 0.9142-1.0568 for Cmax -0,9371 -1,0473. The study concluded that comparable drugs were bioequivalence of bisoprolol.
Item Description:2587-7836
2686-8830

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