Long-Term PDE-5A Inhibition Improves Myofilament Function in Left and Right Ventricular Cardiomyocytes through Partially Different Mechanisms in Diabetic Rat Hearts

• Main Authors: Beáta Bódi (Author), Árpád Kovács (Author), Hajnalka Gulyás (Author), Lilla Mártha (Author), Attila Tóth (Author), Csaba Mátyás (Author), Bálint András Barta (Author), Attila Oláh (Author), Béla Merkely (Author), Tamás Radovits (Author), Zoltán Papp (Author)
• Format: Book
• Published: MDPI AG, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Heart failure with preserved ejection fraction (HFpEF) and right ventricular (RV) dysfunction are frequent complications of diabetic cardiomyopathy. Here we aimed to characterize RV and left ventricular (LV) remodeling and its prevention by vardenafil (a long-acting phosphodiesterase-5A (PDE-5A) inh...