Protective Signature of IFNγ-Stimulated Microglia Relies on miR-124-3p Regulation From the Secretome Released by Mutant APP Swedish Neuronal Cells
Microglia-associated inflammation and miRNA dysregulation are key players in Alzheimer's disease (AD) pathophysiology. Previously, we showed miR-124 upregulation in APP Swedish SH-SY5Y (SWE) and PSEN1 iPSC-derived neurons and its propagation by the secretome (soluble and exosomal fractions). Af...
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Main Authors: | Gonçalo Garcia (Author), Adelaide Fernandes (Author), Frank Stein (Author), Dora Brites (Author) |
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Format: | Book |
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Frontiers Media S.A.,
2022-05-01T00:00:00Z.
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