Clinical utility of cerebrospinal fluid-placental alkaline phosphatase for the diagnosis of intracranial germinoma

• Main Authors: Satoshi Obu (Author), Katsutsugu Umeda (Author), Kougoro Iwanaga (Author), Satoshi Saida (Author), Itaru Kato (Author), Hidefumi Hiramatsu (Author), Yohei Mineharu (Author), Yoshiki Arakawa (Author), Megumi Uto (Author), Takashi Mizowaki (Author), Souichi Adachi (Author), Tomoo Daifu (Author), Masahiko Kawai (Author), Junko Takita (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

The clinical utility of measuring cerebrospinal fluid placental alkaline phosphatase (CSF-PLAP) was evaluated in three patients with germinoma. CSF-PLAP was elevated in two patients with suprasellar germinoma who were symptomatic before developing typical radiological findings. The third patient, who had been radiologically diagnosed with a pineal mature teratoma, was suspected of having a germinoma component due to elevated CSF-PLAP; this patient received adjuvant radiochemotherapy. The presence of a germinoma-specific tumor marker may aid in the early diagnosis of suspicious cases at initial clinical presentation and in the accurate subtype classification of intracranial germ cell tumors.

Item Description

2468-1245
10.1016/j.phoj.2022.10.252