Boc modifies the holoprosencephaly spectrum of Cdo mutant mice

• 主要な著者: Wei Zhang (著者), Mingi Hong (著者), Gyu-un Bae (著者), Jong-Sun Kang (著者), Robert S. Krauss (著者)
• フォーマット: 図書
• 出版事項: The Company of Biologists, 2011-05-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

SUMMARY Holoprosencephaly (HPE) is caused by a failure to form the midline of the forebrain and/or midface. It is one of the most common human birth defects, but clinical expression is extremely variable. HPE is associated with mutations in the sonic hedgehog (SHH) pathway. Mice lacking the Shh path...