Investigation on the Combined Effect of Hydroxypropyl Beta-Cyclodextrin (HPβCD) and Polysorbate in Monoclonal Antibody Formulation

• প্রধান লেখক: Jiayi Huang (লেখক), Shiqi Hong (লেখক), Lucas Yuan Hao Goh (লেখক), Hailong Zhang (লেখক), Tao Peng (লেখক), Keat Theng Chow (লেখক), Rajeev Gokhale (লেখক), Vinod Tuliani (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: MDPI AG, 2024-04-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Monoclonal antibodies require careful formulation due to their inherent stability limitations. Polysorbates are commonly used to stabilize mAbs, but they are prone to degradation, which results in unwanted impurities. KLEPTOSE^® HPβCD (hydroxypropyl beta-cyclodextrin) has funct...