Investigation on the Combined Effect of Hydroxypropyl Beta-Cyclodextrin (HPβCD) and Polysorbate in Monoclonal Antibody Formulation

• Κύριοι συγγραφείς: Jiayi Huang (Συγγραφέας), Shiqi Hong (Συγγραφέας), Lucas Yuan Hao Goh (Συγγραφέας), Hailong Zhang (Συγγραφέας), Tao Peng (Συγγραφέας), Keat Theng Chow (Συγγραφέας), Rajeev Gokhale (Συγγραφέας), Vinod Tuliani (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: MDPI AG, 2024-04-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Monoclonal antibodies require careful formulation due to their inherent stability limitations. Polysorbates are commonly used to stabilize mAbs, but they are prone to degradation, which results in unwanted impurities. KLEPTOSE^® HPβCD (hydroxypropyl beta-cyclodextrin) has funct...