Investigation on the Combined Effect of Hydroxypropyl Beta-Cyclodextrin (HPβCD) and Polysorbate in Monoclonal Antibody Formulation

• मुख्य लेखकों: Jiayi Huang (लेखक), Shiqi Hong (लेखक), Lucas Yuan Hao Goh (लेखक), Hailong Zhang (लेखक), Tao Peng (लेखक), Keat Theng Chow (लेखक), Rajeev Gokhale (लेखक), Vinod Tuliani (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2024-04-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Monoclonal antibodies require careful formulation due to their inherent stability limitations. Polysorbates are commonly used to stabilize mAbs, but they are prone to degradation, which results in unwanted impurities. KLEPTOSE^® HPβCD (hydroxypropyl beta-cyclodextrin) has funct...