Investigation on the Combined Effect of Hydroxypropyl Beta-Cyclodextrin (HPβCD) and Polysorbate in Monoclonal Antibody Formulation

• Главные авторы: Jiayi Huang (Автор), Shiqi Hong (Автор), Lucas Yuan Hao Goh (Автор), Hailong Zhang (Автор), Tao Peng (Автор), Keat Theng Chow (Автор), Rajeev Gokhale (Автор), Vinod Tuliani (Автор)
• Формат: ‌
• Опубликовано: MDPI AG, 2024-04-01T00:00:00Z.
• Предметы: article
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Monoclonal antibodies require careful formulation due to their inherent stability limitations. Polysorbates are commonly used to stabilize mAbs, but they are prone to degradation, which results in unwanted impurities. KLEPTOSE^® HPβCD (hydroxypropyl beta-cyclodextrin) has funct...