Investigation on the Combined Effect of Hydroxypropyl Beta-Cyclodextrin (HPβCD) and Polysorbate in Monoclonal Antibody Formulation

• Main Authors: Jiayi Huang (Author), Shiqi Hong (Author), Lucas Yuan Hao Goh (Author), Hailong Zhang (Author), Tao Peng (Author), Keat Theng Chow (Author), Rajeev Gokhale (Author), Vinod Tuliani (Author)
• 格式: 图书
• 出版: MDPI AG, 2024-04-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

Monoclonal antibodies require careful formulation due to their inherent stability limitations. Polysorbates are commonly used to stabilize mAbs, but they are prone to degradation, which results in unwanted impurities. KLEPTOSE^® HPβCD (hydroxypropyl beta-cyclodextrin) has funct...