Toxicological evaluation of microbial secondary metabolites in the context of European active substance approval for plant protection products

• Main Authors: Norman Paege (Author), Sabrina Feustel (Author), Philip Marx-Stoelting (Author)
• Format: Book
• Published: BMC, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 10.1186/s12940-024-01092-0; 1476-069X
• Keywords: Plant protection active substance; Beauvericin; 2,3-deepoxy-2,3-didehydro-rhizoxin; Leucinostatin A; Swainsonin; Microbial secondary metabolites; Industrial medicine. Industrial hygiene; RC963-969; Public aspects of medicine; RA1-1270
• Source: Environmental Health, Vol 23, Iss 1, Pp 1-14 (2024)

Abstract Risk assessment (RA) of microbial secondary metabolites (SM) is part of the EU approval process for microbial active substances (AS) used in plant protection products (PPP). As the number of potentially produced microbial SM may be high for a certain microbial strain and existing information on the metabolites often are low, data gaps are frequently identified during the RA. Often, RA cannot conclusively clarify the toxicological relevance of the individual substances. This work presents data and RA conclusions on four metabolites, Beauvericin, 2,3-deepoxy-2,3-didehydro-rhizoxin (DDR), Leucinostatin A and Swainsonin in detail as examples for the challenging process of RA. To overcome the problem of incomplete assessment reports, RA of microbial AS for PPP is in need of new approaches. In view of the Next Generation Risk Assessment (NGRA), the combination of literature data, omic-methods, in vitro and in silico methods combined in adverse outcome pathways (AOPs) can be used for an efficient and targeted identification and assessment of metabolites of concern (MoC).