Multidrug Resistance Protein-4 Influences Aspirin Toxicity in Human Cell Line

• Main Authors: Isabella Massimi (Author), Ambra Ciuffetta (Author), Flavia Temperilli (Author), Francesca Ferrandino (Author), Alessandra Zicari (Author), Fabio M. Pulcinelli (Author), Maria Pia Felli (Author)
• Format: Book
• Published: Hindawi Limited, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Overexpression of efflux transporters, in human cells, is a mechanism of resistance to drug and also to chemotherapy. We found that multidrug resistance protein-4 (MRP4) overexpression has a role in reducing aspirin action in patients after bypass surgery and, very recently, we found that aspirin en...