Correlations Between the Density of Tryptase Positive Mast Cells (DMCT) and that of New Blood Vessels (CD105+) in Patients with Gastric Cancer

• Main Authors: Micu Gianina Viorica (Author), Stăniceanu Florica (Author), Sticlaru Liana Cătălina (Author), Popp Cristiana Gabriela (Author), Bastian Alexandra Eugenia (Author), Gramada Eliza (Author), Pop. G. (Author), Mateescu R. B. (Author), Rimbaş M. (Author), Archip Bianca (Author), Bleotu Coralia (Author)
• Format: Book
• Published: Sciendo, 2016-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2501-062X; 10.1515/rjim-2016-0016
• Keywords: gastric cancer; mast cells; tryptase; new vessel density; helicobacter pylori infection; Internal medicine; RC31-1245
• Source: Romanian Journal of Internal Medicine, Vol 54, Iss 2, Pp 113-120 (2016)

Mast cells proteases, tryptase and chymase are directly involved in the growth and progression of solid tumors due to their important role in tumor angiogenesis. We examined the density of tryptase positive mast cells and the mean density of new blood vessels in gastric malignant tumors of patients with and without Helicobacter pylori infection, using immunohistochemical staining for tryptase (for mast cells) and CD 105 (for new vessels). Tryptase and CD 105 expression was detected in gastrectomy specimens. In this study, mast cell density correlates with angiogenesis and the growth and progression of gastric cancer. It also shows that the participation of Helicobacter pylori infection in the growth and progress of gastric neoplasia is due to an increase of peritumoral angiogenesis, with subsequent local and distant tumor spread and perivascular growth, but without perineural and nodal involvement.