PET Imaging with [¹⁸F]ROStrace Detects Oxidative Stress and Predicts Parkinson's Disease Progression in Mice

• Main Authors: Yi Zhu (Author), Neha Kohli (Author), Anthony Young (Author), Malkah Sheldon (Author), Jani Coni (Author), Meera Rajasekaran (Author), Lozen Robinson (Author), Rea Chroneos (Author), Shaipreeah Riley (Author), Joseph W. Guarnieri (Author), Joshua Jose (Author), Nisha Patel (Author), Douglas C. Wallace (Author), Shihong Li (Author), Hsiaoju Lee (Author), Robert H. Mach (Author), Meagan J. McManus (Author)
• Format: Book
• Published: MDPI AG, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although the precise molecular mechanisms responsible for neuronal death and motor dysfunction in late-onset Parkinson's disease (PD) are unknown, evidence suggests that mitochondrial dysfunction and neuroinflammation occur early, leading to a collective increase in reactive oxygen species (ROS...