Formulation and Evaluation of Sustained Release Sumatriptan Mucoadhesive Intranasal in-Situ Gel
Objective: The purpose of this study to develop and optimize nasal mucoadhesive in situ gel IG of sumatriptan ST (serotonin agonist) to enhance nasal residence time for migraine management. Method: Cold method was used to prepare ST nasal in-situ gel, using thermosensitive polymers (poloxamer 4...
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| Main Authors: | , |
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| Format: | Book |
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College of Pharmacy University of Baghdad,
2019-12-01T00:00:00Z.
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| Summary: | Objective: The purpose of this study to develop and optimize nasal mucoadhesive in situ gel IG of sumatriptan ST (serotonin agonist) to enhance nasal residence time for migraine management. Method: Cold method was used to prepare ST nasal in-situ gel, using thermosensitive polymers (poloxamer 407 and/or poloxamer 188) with a mucoadhesive polymer (hyaluronic acid HA) which were examined for gelation temperature and gelation time, pH, drug content, gel strength, spreadability, mucoadhesive force determination, viscosity, in-vitro drug release, and the selected formula was subjected to ex-vivo permeation study and histological evaluation of the sheep mucosal tissue after application. Results: The results showed that the formula IG7 prepared from poloxamer 407(19%), poloxamer188 (4%) and HA (0.5%) had an optimum gelation temperature (32.66±1.52°C), gel strength (43.66± 1.52 sec), mucoadhesive force (8067.93± 746.45dyne\cm2), in-vitro drug release (95.98%) over 6hr, ex-vivo permeation study release (89.6%) during the 6 h. study with no histological or pathological change in the nasal sheep tissue. Conclusion: The ease of administration via a nasal drop of ST coupled with less frequent administration and prolong drug release, will enhance patient compliance. |
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| Item Description: | 2521-3512 1683-3597 10.31351/vol28iss2pp95-104 |