Effect of Decreased Levels of Intrinsic Tetrahydrobiopterin on Endothelial Function in Anesthetized Rats

• Main Authors: Naobumi Hamadate (Author), Katsuhiko Noguchi (Author), Mayuko Sakanashi (Author), Toshihiro Matsuzaki (Author), Junko Nakasone (Author), Matao Sakanashi (Author)
• Format: Book
• Published: Elsevier, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tetrahydrobiopterin (BH4) deficiency has been suggested to be an important factor in vascular endothelial dysfunction. In this study, we investigated the influence of decreased BH4 level produced by administration of 2,4-diamino-6-hydroxypyrimidine (DAHP), a specific inhibitor of the rate-limiting e...