Immune exhaustion in chronic Chagas disease: Pro-inflammatory and immunomodulatory action of IL-27 in vitro.

• मुख्य लेखकों: María Ailén Natale (लेखक), Todd Minning (लेखक), María Cecilia Albareda (लेखक), Melisa Daiana Castro Eiro (लेखक), María Gabriela Álvarez (लेखक), Bruno Lococo (लेखक), Gonzalo Cesar (लेखक), Graciela Bertocchi (लेखक), María Josefina Elias (लेखक), María Belén Caputo (लेखक), Rick Lee Tarleton (लेखक), Susana Adriana Laucella (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Public Library of Science (PLoS), 2021-06-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

In chronic Chagas disease, Trypanosoma cruzi-specific T-cell function decreases over time, and alterations in the homeostatic IL-7/IL-7R axis are evident, consistent with a process of immune exhaustion. IL-27 is an important immunoregulatory cytokine that shares T-cell signaling with IL-7 and other...