A Novel Approach to Improve Newborn Screening for Congenital Hypothyroidism by Integrating Covariate-Adjusted Results of Different Tests into CLIR Customized Interpretive Tools

• Main Authors: Alexander D. Rowe (Author), Stephanie D. Stoway (Author), Henrik Åhlman (Author), Vaneet Arora (Author), Michele Caggana (Author), Anna Fornari (Author), Arthur Hagar (Author), Patricia L. Hall (Author), Gregg C. Marquardt (Author), Bobby J. Miller (Author), Christopher Nixon (Author), Andrew P. Norgan (Author), Joseph J. Orsini (Author), Rolf D. Pettersen (Author), Amy L. Piazza (Author), Neil R. Schubauer (Author), Amy C. Smith (Author), Hao Tang (Author), Norma P. Tavakoli (Author), Sainan Wei (Author), Rolf H. Zetterström (Author), Robert J. Currier (Author), Lars Mørkrid (Author), Piero Rinaldo (Author)
• Format: Book
• Published: MDPI AG, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Newborn screening for congenital hypothyroidism remains challenging decades after broad implementation worldwide. Testing protocols are not uniform in terms of targets (TSH and/or T4) and protocols (parallel vs. sequential testing; one or two specimen collection times), and specificity (with or with...