Pharmacokinetic modeling of morphine and its glucuronides: Comparison of nebulization versus intravenous route in healthy volunteers

• Main Authors: Thomas Duflot (Author), Tony Pereira (Author), Marie‐Pierre Tavolacci (Author), Robinson Joannidès (Author), Frédéric Aubrun (Author), Fabien Lamoureux (Author), Virginie Eve Lvovschi (Author)
• Format: Book
• Published: Wiley, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Intravenous (i.v.) morphine is a safe, robust, and recommended treatment for severe pain using the titration principle. Despite its high efficacy, it is impacted by organizational constraints related to venous access. Nebulized (NEB) morphine may represent an alternative for titration but p...