Evaluation of guanidine antifungal solutions for denture base resin: an in vitro study

Background: The purposes of this study were: (1) to formulate polyhexamethylene guanidine hydrochloride (PHMGH) solutions at different concentrations; (2) to evaluate their antifungal activity against a mature biofilm of Candida albicans on acrylic resins; (3) to evaluate possible effects on acrylic...

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Main Authors: Maria Eduarda Rodrigues Gama (Author), Vicente Castelo Branco Leitune (Author), Isadora Martini Garcia (Author), Stéfani Becker Rodrigues (Author), Fabrício Mezzomo Collares (Author)
Format: Book
Published: Universidade Federal do Rio Grande do Sul. Faculdade de Odontologia, 2020-12-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Maria Eduarda Rodrigues Gama  |e author 
700 1 0 |a Vicente Castelo Branco Leitune  |e author 
700 1 0 |a Isadora Martini Garcia  |e author 
700 1 0 |a Stéfani Becker Rodrigues  |e author 
700 1 0 |a Fabrício Mezzomo Collares  |e author 
245 0 0 |a Evaluation of guanidine antifungal solutions for denture base resin: an in vitro study 
260 |b Universidade Federal do Rio Grande do Sul. Faculdade de Odontologia,   |c 2020-12-01T00:00:00Z. 
500 |a 0566-1854 
500 |a 2177-0018 
500 |a 10.22456/2177-0018.104096 
520 |a Background: The purposes of this study were: (1) to formulate polyhexamethylene guanidine hydrochloride (PHMGH) solutions at different concentrations; (2) to evaluate their antifungal activity against a mature biofilm of Candida albicans on acrylic resins; (3) to evaluate possible effects on acrylic resins flexural strength and surface roughness. Methods: PHMGH solutions were formulated with distilled water and 0.125, 0.250, or 0.5 wt.% of PHMGH. One group without PHMGH was used as control. For antifungal activity analysis, acrylic resin specimens were contaminated with C. albicans. Specimens were immersed in PHMGH solutions or distilled water for 5 or 10 min. Ultimate flexural strength and surface roughness of acrylic resins were evaluated. Results: All PHMGH solutions at 5 or 10 min showed antifungal activity compared to the control group (p 
546 |a EN 
546 |a PT 
690 |a acrylic resins 
690 |a antifungal agents 
690 |a candidiasis 
690 |a guanidine 
690 |a dentures 
690 |a Dentistry 
690 |a RK1-715 
655 7 |a article  |2 local 
786 0 |n Revista da Faculdade de Odontologia de Porto Alegre, Vol 61, Iss 2, Pp 39-49 (2020) 
787 0 |n https://seer.ufrgs.br/RevistadaFaculdadeOdontologia/article/view/104096 
787 0 |n https://doaj.org/toc/0566-1854 
787 0 |n https://doaj.org/toc/2177-0018 
856 4 1 |u https://doaj.org/article/06b249ea138445d598c95916d6af6e15  |z Connect to this object online.