Amentoflavone Attenuates Clostridium perfringens Gas Gangrene by Targeting Alpha-Toxin and Perfringolysin O

• Main Authors: Shui Liu (Author), Xiaofeng Yang (Author), Hong Zhang (Author), Jian Zhang (Author), Yonglin Zhou (Author), Tingting Wang (Author), Naiyu Hu (Author), Xuming Deng (Author), Xiaoxue Bai (Author), Jianfeng Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Clostridium perfringens (C. perfringens) type A strains are the main cause of gas gangrene in humans and animals. Treatment of this lethal disease is limited, and the prognosis is not good. Alpha-toxin (CPA) and perfringolysin O (PFO) secreted by C. perfringens play irreplaceable roles in cytotoxici...