Nitric oxide production in murine spleen cells: role of interferons and prostaglandin E2 in the generation of cytotoxic activity

• Main Authors: Dominique Vaillier (Author), Richard Daculsi (Author), Norbert Gualdel (Author)
• Formato: Libro
• Publicado: Hindawi Limited, 1996-01-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

The production of nitric oxide (NO) was measured in cultures of spleen cells stimulated by lipopolysaccharide (LPS), IL-2 or LPS + IL-2. We observed that NO synthesis is increased by IFN-γ but inhibited by IFN-α/β. This is not the case when IL-2 is present in the cultures, since interferons play a m...