Cover Image

Sitagliptin, An Anti-diabetic Drug, Suppresses Estrogen Deficiency-Induced OsteoporosisIn Vivo and Inhibits RANKL-Induced Osteoclast Formation and Bone Resorption In Vitro

Postmenopausal osteoporosis is a disease characterized by excessive osteoclastic bone resorption. Some anti-diabetic drugs were demonstrated for anti-osteoclastic bone-loss effects. The present study investigated the skeletal effects of chronic administration of sitagliptin, a dipeptidyl peptidase I...

Full description

Saved in:

Bibliographic Details
Main Authors:	Chuandong Wang (Author), Fei Xiao (Author), Xinhua Qu (Author), Zanjing Zhai (Author), Guoli Hu (Author), Xiaodong Chen (Author), Xiaoling Zhang (Author)
Format:	Book
Published:	Frontiers Media S.A., 2017-06-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

The Beneficial Effect of Praeruptorin C on Osteoporotic Bone in Ovariectomized Mice via Suppression of Osteoclast Formation and Bone Resorption
by: Xuqiang Liu, et al.
Published: (2017)

Inhibitory Effects of Rhaponticin on Osteoclast Formation and Resorption by Targeting RANKL-Induced NFATc1 and ROS Activity
by: Jianbo He, et al.
Published: (2021)

Nardosinone Suppresses RANKL-Induced Osteoclastogenesis and Attenuates Lipopolysaccharide-Induced Alveolar Bone Resorption
by: Chenguang Niu, et al.
Published: (2017)

Corrigendum: Inhibitory effects of Rhaponticin on osteoclast formation and resorption by targeting RANKL-induced NFATc1 and ROS activity
by: Jianbo He, et al.
Published: (2023)

Dendrobium officinale Orchid Extract Prevents Ovariectomy-Induced Osteoporosis in Vivo and Inhibits RANKL-Induced Osteoclast Differentiation in Vitro
by: Qi Wang, et al.
Published: (2018)

Plumbagin modulates RANKL-induced osteoclast and osteoblast differentiation
by: Soni Ghumnani, et al.
Published: (2023)

Corrigendum: Dendrobium officinale Orchid Extract Prevents Ovariectomy-Induced Osteoporosis In Vivo and Inhibits RANKL-Induced Osteoclast Differentiation In Vitro
by: Qi Wang, et al.
Published: (2020)

Osteoclast activity in osteoporosis mandibular bone based on RANKL and osteoprotegerin ratio.
by: Mefina Kuntjoro, et al.
Published: (2021)

Artemisinic acid attenuates osteoclast formation and titanium particle-induced osteolysis via inhibition of RANKL-induced ROS accumulation and MAPK and NF-κB signaling pathways
by: Tian Gao, et al.
Published: (2024)

Notopterol Attenuates Estrogen Deficiency-Induced Osteoporosis via Repressing RANKL Signaling and Reactive Oxygen Species
by: Delong Chen, et al.
Published: (2021)

Flavopiridol Protects Bone Tissue by Attenuating RANKL Induced Osteoclast Formation
by: Zi'ang Hu, et al.
Published: (2018)

α-1 Antitrypsin Inhibits RANKL-induced Osteoclast Formation and Functions
by: Mohammad Ahsanul Akbar, et al.
Published: (2017)

Fumitremorgin C Attenuates Osteoclast Formation and Function via Suppressing RANKL-Induced Signaling Pathways
by: Yu Yuan, et al.
Published: (2020)

CYT387, a JAK-Specific Inhibitor Impedes Osteoclast Activity and Oophorectomy-Induced Osteoporosis via Modulating RANKL and ROS Signaling Pathways
by: Jing Li, et al.
Published: (2022)

Inhibitory Effect of Cudratrixanthone U on RANKL-Induced Osteoclast Differentiation and Function in Macrophages and BMM Cells
by: Eun-Nam Kim, et al.
Published: (2020)

Nrf2 Mitigates RANKL and M-CSF Induced Osteoclast Differentiation via ROS-Dependent Mechanisms
by: Yang Yang, et al.
Published: (2023)

Phosphorylation of BCL2 at the Ser70 site mediates RANKL-induced osteoclast precursor autophagy and osteoclastogenesis
by: Dianshan Ke, et al.
Published: (2022)

Liquiritigenin reduces osteoclast activity in zebrafish model of glucocorticoid-induced osteoporosis
by: Marta Carnovali, et al.
Published: (2020)

Pantoprazole (PPZ) Inhibits RANKL-Induced Osteoclast Formation and Function In Vitro and Prevents Lipopolysaccharide- (LPS-) Induced Inflammatory Calvarial Bone Loss In Vivo
by: Yu-Xi Li, et al.
Published: (2020)

Genipin Inhibits RANKL-Induced Osteoclast Differentiation Through Proteasome-Mediated Degradation of c-Fos Protein and Suppression of NF-κB Activation
by: Chang Hoon Lee, et al.
Published: (2014)

Chaenomelis fructus inhibits osteoclast differentiation by suppressing NFATc1 expression and prevents ovariectomy-induced osteoporosis
by: Minsun Kim, et al.
Published: (2020)

Dual effect of aucubin on promoting VEGFR2 mediated angiogenesis and reducing RANKL-induced bone resorption
by: Yulin He, et al.
Published: (2023)

Baicalin Ameliorates Dexamethasone-Induced Osteoporosis by Regulation of the RANK/RANKL/OPG Signaling Pathway
by: Zhao Y, et al.
Published: (2020)

Cirsilineol inhibits RANKL-induced osteoclast activity and ovariectomy-induced bone loss via NF-κb/ERK/p38 signaling pathways
by: Cong Wang, et al.
Published: (2024)

CpG Oligodeoxynucleotides Inhibit RANKL-Induced Osteoclast Formation by Upregulating A20 Deubiquitinase in RAW 264.7 Cells
by: Seong-Kyu Kim, et al.
Published: (2022)

Pristimerin Inhibits Osteoclast Differentiation and Bone Resorption in vitro and Prevents Ovariectomy-Induced Bone Loss in vivo
by: Sun P, et al.
Published: (2020)

Cepharanthine Prevents Estrogen Deficiency-Induced Bone Loss by Inhibiting Bone Resorption
by: Chen-he Zhou, et al.
Published: (2018)

Erratum to: Sophorae Flos extract inhibits RANKL-induced osteoclast differentiation by suppressing the NF-κB/NFATc1 pathway in mouse bone marrow cells
by: Jeong-Mi Kim, et al.
Published: (2017)

Boldine Ameliorates Estrogen Deficiency-Induced Bone Loss via Inhibiting Bone Resorption
by: Kun Chen, et al.
Published: (2018)

Hesperetin Prevents Bone Resorption by Inhibiting RANKL-Induced Osteoclastogenesis and Jnk Mediated Irf-3/c-Jun Activation
by: Qiang Zhang, et al.
Published: (2018)

Molecular Hydrogen Prevents Osteoclast Activation in a Glucocorticoid-Induced Osteoporosis Zebrafish Scale Model
by: Marta Carnovali, et al.
Published: (2023)

Water Extract of Mentha arvensis L. Attenuates Estrogen Deficiency-Induced Bone Loss by Inhibiting Osteoclast Differentiation
by: Seon-A Jang, et al.
Published: (2021)

Effect of Estrogen on the Activity and Growth of Human Osteoclasts In Vitro
by: Fang-Ping Chen, et al.
Published: (2009)

Gamabufotalin Inhibits Osteoclastgenesis and Counteracts Estrogen-Deficient Bone Loss in Mice by Suppressing RANKL-Induced NF-κB and ERK/MAPK Pathways
by: Kaiqiang Sun, et al.
Published: (2021)

3,3'-Diindolylmethane increases bone mass by suppressing osteoclastic bone resorption in mice
by: Tai-yong Yu, et al.
Published: (2015)

Pristimerin Suppresses RANKL-Induced Osteoclastogenesis and Ameliorates Ovariectomy-Induced Bone Loss
by: Dahu Qi, et al.
Published: (2021)

Effects of treatment with sitagliptin on hepatotoxicity induced by acetaminophen in mice
by: Wafaa Ahmed Hewedy
Published: (2021)

Mechanical force regulates root resorption in rats through RANKL and OPG
by: Jianli Zhou, et al.
Published: (2022)

The RANKL expression and osteoclast in alveolar bone of rat diabetic model at different mechanical force application
by: Nuzulul Hikmah, et al.
Published: (2018)

The Immunologic Relationship between Root Resorptions and Osteoclastic Activity - Literature Review
by: Luciano Silva, et al.
Published: (2016)