Role of miRNA dysregulation in sepsis

Abstract Background Sepsis is defined as a state of multisystem organ dysfunction secondary to a dysregulated host response to infection and causes millions of deaths worldwide annually. Novel ways to counteract this disease are needed and such tools may be heralded by a detailed understanding of it...

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Main Authors: Amanda Formosa (Author), Paul Turgeon (Author), Claudia C. dos Santos (Author)
Format: Book
Published: BMC, 2022-08-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Amanda Formosa  |e author 
700 1 0 |a Paul Turgeon  |e author 
700 1 0 |a Claudia C. dos Santos  |e author 
245 0 0 |a Role of miRNA dysregulation in sepsis 
260 |b BMC,   |c 2022-08-01T00:00:00Z. 
500 |a 10.1186/s10020-022-00527-z 
500 |a 1076-1551 
500 |a 1528-3658 
520 |a Abstract Background Sepsis is defined as a state of multisystem organ dysfunction secondary to a dysregulated host response to infection and causes millions of deaths worldwide annually. Novel ways to counteract this disease are needed and such tools may be heralded by a detailed understanding of its molecular pathogenesis. MiRNAs are small RNA molecules that target mRNAs to inhibit or degrade their translation and have important roles in several disease processes including sepsis. Main body The current review adopted a strategic approach to analyzing the widespread literature on the topic of miRNAs and sepsis. A pubmed search of "miRNA or microRNA or small RNA and sepsis not review" up to and including January 2021 led to 1140 manuscripts which were reviewed. Two hundred and thirty-three relevant papers were scrutinized for their content and important themes on the topic were identified and subsequently discussed, including an in-depth look at deregulated miRNAs in sepsis in peripheral blood, myeloid derived suppressor cells and extracellular vesicles. Conclusion Our analysis yielded important observations. Certain miRNAs, namely miR-150 and miR-146a, have consistent directional changes in peripheral blood of septic patients across numerous studies with strong data supporting a role in sepsis pathogenesis. Furthermore, a large body of literature show miRNA signatures of clinical relevance, and lastly, many miRNAs deregulated in sepsis are associated with the process of endothelial dysfunction. This review offers a widespread, up-to-date and detailed discussion of the role of miRNAs in sepsis and is meant to stimulate further work in the field due to the potential of these small miRNAs in prompt diagnostics, prognostication and therapeutic agency. 
546 |a EN 
690 |a miRNAs 
690 |a Small RNAs 
690 |a Sepsis 
690 |a Septic shock 
690 |a Endothelium 
690 |a Extracellular vesicles 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
690 |a Biochemistry 
690 |a QD415-436 
655 7 |a article  |2 local 
786 0 |n Molecular Medicine, Vol 28, Iss 1, Pp 1-16 (2022) 
787 0 |n https://doi.org/10.1186/s10020-022-00527-z 
787 0 |n https://doaj.org/toc/1076-1551 
787 0 |n https://doaj.org/toc/1528-3658 
856 4 1 |u https://doaj.org/article/070fb13ee4484e67ae0e90b51fea712c  |z Connect to this object online.