First isolation and characterization of SARS-CoV-2 from COVID-19 patient of North East India

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) responsible for the current pandemic has resulted in over 5 million deaths globally. More than a year has passed, still SARS-CoV-2 panic the public life. Virus isolation is of paramount importance for development of vaccines, in-vitro scre...

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Bibliographic Details
Main Authors: Aniruddha Jakharia (Author), Biswajyoti Borkakoty (Author), Sumi Pait (Author), Gautam Baruah (Author), Rahul Hazarika (Author), Dipankar Biswas (Author)
Format: Book
Published: Wolters Kluwer Medknow Publications, 2024-01-01T00:00:00Z.
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700 1 0 |a Rahul Hazarika  |e author 
700 1 0 |a Dipankar Biswas  |e author 
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520 |a Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) responsible for the current pandemic has resulted in over 5 million deaths globally. More than a year has passed, still SARS-CoV-2 panic the public life. Virus isolation is of paramount importance for development of vaccines, in-vitro screening of antiviral compounds, pathogenesis studies, etc., Many cell lines were studied for amplification and replication of SARS-CoV-2 and Vero cells were found to be ideal cell lines for isolation. In May 2020, ICMR-Regional Medical Research Centre, NE region, India, successfully established the SARS-CoV-2 culture system in Vero CCL-81 cell lines. Phylogenetic analyses of the whole genome sequences of the SARS-CoV-2 isolate (EPI_ISL_2501532 | 2020-05-19) showed monophyletic clade G and lineage B.1.1. 
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786 0 |n Indian Journal of Pathology and Microbiology, Vol 67, Iss 1, Pp 133-139 (2024) 
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