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Torsadogenic potential of a novel remyelinating drug clemastine for multiple sclerosis assessed in the rabbit proarrhythmia model

We assessed the torsadogenic effects of a novel remyelinating drug clemastine for multiple sclerosis using an in vivo proarrhythmia model of acute atrioventricular block rabbit, since the drug has been demonstrated to suppress the human ether-á-go-go related gene (hERG) K+ channels. Bradycardia was...

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Main Authors:	Satoshi Kawakami (Author), Yoshinobu Nagasawa (Author), Mihoko Hagiwara-Nagasawa (Author), Kensuke Omura (Author), Megumi Aimoto (Author), Akira Takahara (Author)
Format:	Book
Published:	Elsevier, 2020-11-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
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