Knockdown resistance mutations are common and widely distributed in Xenopsylla cheopis fleas that transmit plague in Madagascar.

• Main Authors: Shelby M Hutton (Author), Adelaide Miarinjara (Author), Nathan E Stone (Author), Fara N Raharimalala (Author), Annick O Raveloson (Author), Ravo Rakotobe Harimanana (Author), Mireille Harimalala (Author), Soanandrasana Rahelinirina (Author), Ryelan F McDonough (Author), Abbe D Ames (Author), Crystal Hepp (Author), Minoarisoa Rajerison (Author), Joseph D Busch (Author), David M Wagner (Author), Romain Girod (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>Plague, caused by the bacterium Yersinia pestis, remains an important disease in Madagascar, where the oriental rat flea, Xenopsylla cheopis, is a primary vector. To control fleas, synthetic pyrethroids (SPs) have been used for >20 years, resulting in resistance in...