Recombinant vesicular stomatitis virus vaccine vectors expressing filovirus glycoproteins lack neurovirulence in nonhuman primates.

• Main Authors: Chad E Mire (Author), Andrew D Miller (Author), Angela Carville (Author), Susan V Westmoreland (Author), Joan B Geisbert (Author), Keith G Mansfield (Author), Heinz Feldmann (Author), Lisa E Hensley (Author), Thomas W Geisbert (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The filoviruses, Marburg virus and Ebola virus, cause severe hemorrhagic fever with high mortality in humans and nonhuman primates. Among the most promising filovirus vaccines under development is a system based on recombinant vesicular stomatitis virus (rVSV) that expresses an individual filovirus...