Comparing the Phylogenetic Distribution of Multilocus Sequence Typing, Staphylococcal Protein A, and Staphylococcal Cassette Chromosome Mec Types in Methicillin-Resistant Staphylococcus Aureus (MRSA) in Korea from 1994 to 2020
<i>Staphylococcus aureus</i> (<i>S. aureus</i>) bacteremia is one of the most frequent and severe bacterial infections worldwide. Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) is a serious human pathogen that can cause a wide variety of infections. Com...
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Published: |
MDPI AG,
2023-09-01T00:00:00Z.
|
| Subjects: | |
| Online Access: | Connect to this object online. |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | <i>Staphylococcus aureus</i> (<i>S. aureus</i>) bacteremia is one of the most frequent and severe bacterial infections worldwide. Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) is a serious human pathogen that can cause a wide variety of infections. Comparative genetic analyses have shown that despite the existence of a vast number of genotypes, genotypes are restricted to certain geographical locations. By comparing multilocus sequence typing (MLST) and <i>SCCmec</i> types from 1994 to 2020, the present study intended to discover which genotype genes were related to MRSA infections. MLST, <i>Staphylococcus aureus</i> protein A (spa), and <i>SCCmec</i> typings were performed to determine their relationship during those years. Results revealed that MRSA isolates in the Republic of Korea were distributed among all major staphylococcal cassette chromosome <i>mec</i> (<i>SCCmec</i>) types. The majority of <i>SCCmec</i> isolates belonged to <i>SCCmec</i> type II and type IV. The majority of MLST had the sequence type (ST) 72, 239, 8, or 188. By contrast, minorities belonged to ST22 (SCC<i>mec</i> IV), ST772 (SCC<i>mec</i> V), and ST672 (SCC<i>mec</i> V) genotypes. The <i>SCCmec</i> type was determined for various types. The <i>spa</i> type was dispersed, seemingly regardless of its multidrug resistance property. The MLST type was found to be similar to the existing typical type. These results showed some correlations between resistance characteristics and types according to the characteristics of the MLST types distributed, compared to previous papers. Reports on genotype distribution of MLST and <i>SCCmec</i> types in MRSA are rare. These results show a clear distribution of MLST and <i>SCCmec</i> types of MRSA from 1994 to 2020 in the Republic of Korea. |
|---|---|
| Item Description: | 10.3390/antibiotics12091397 2079-6382 |