"Stapling" scFv for multispecific biotherapeutics of superior properties

• Main Authors: Lauren E. Boucher (Author), Elisabeth Geyer Prinslow (Author), Michael Feldkamp (Author), Fang Yi (Author), Rupesh Nanjunda (Author), Sheng-Jiun Wu (Author), Tun Liu (Author), Eilyn R. Lacy (Author), Steven Jacobs (Author), Natalia Kozlyuk (Author), Brian Del Rosario (Author), Bingyuan Wu (Author), Patricia Aquino (Author), Robert C. Davidson (Author), Samantha Heyne (Author), Nicholas Mazzanti (Author), James Testa (Author), Michael D. Diem (Author), Elsa Gorre (Author), Andrew Mahan (Author), Hirsh Nanda (Author), Harsha P. Gunawardena (Author), Alexis Gervais (Author), Anthony A. Armstrong (Author), Alexey Teplyakov (Author), Chichi Huang (Author), Adam Zwolak (Author), Partha Chowdhury (Author), Wan Cheung Cheung (Author), Jinquan Luo (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTSingle-chain fragment variable (scFv) domains play an important role in antibody-based therapeutic modalities, such as bispecifics, multispecifics and chimeric antigen receptor T cells or natural killer cells. However, scFv domains exhibit lower stability and increased risk of aggregation du...